Antibody Engineering by Design
Engineering the right molecule for the biology
We engineer antibody formats around biology – rather than forcing biology into a single molecular format. Depending on the target, signaling pathway, and desired therapeutic outcome, we combine flexible molecular formats with precise control of valency, epitope, Fc function, and half-life to achieve precise control over receptor engagement, cell targeting, and effector function.
- Biology-driven format selection: We match classical IgG, monovalent, bispecific, and Fc-fusion formats to the underlying target biology and desired signaling outcome.
- Mechanism by design: We precisely control valency, epitope selection, and Fc gamma receptor engagement to shape therapeutic activity while minimizing unwanted receptor crosslinking or unintended immune activation.
- Platform leverage: Our HERAKL1S platform enables the development of highly selective monovalent antagonists and agonists where controlled receptor engagement and signaling are critical.